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Dietary supplements containing DHEA, the compound that adjustments into hormones like testosterone and estradiol within the physique, do affect physique composition, however don’t count on these results to be dramatic. That is the conclusion that endocrinologists at Maggiore-Bellaria Hospital in Bologna, Italy, draw from a meta-study through which they gathered information from 25 trials and re-analysed them.

Dietary supplements containing DHEA, the compound that adjustments into hormones like testosterone and estradiol within the physique, do affect physique composition, however don’t count on these results to be dramatic. That is the conclusion that endocrinologists at Maggiore-Bellaria Hospital in Bologna, Italy, draw from a meta-study through which they gathered information from 25 trials and re-analysed them.

When DHEA first appeared available on the market as a complement within the early 1990s, producers hailed it because the anti-aging product. DHEA supplementation may reverse nearly each conceivable impact of getting old, if you happen to believed the trade’s claims.

That is not the case. DHEA even suffered from a unfavorable picture for a very long time, till more moderen research began to point out some optimistic results. Most of those research are concerning the impact of DHEA on physique composition by the way in which.

Examine
The Italians have been curious as to whether or not they would observe these optimistic results of DHEA in trials that had concerned older males. They discovered 200, however solely used 25 of those of their meta-study. The typical size of the trials was 36 weeks, and the Italians had information on just below 1400 males in whole.

Outcomes
DHEA supplementation boosted the overall focus of testosterone [TT] within the blood by 1.2 nanomoles per litre, and of estradiol by 25 picomoles per litre, the researchers found. Each results have been statistically vital.

DHEA supplementation triggered a modest discount in fats mass and an much more modest enhance in lean physique mass. The impact on fats mass was statistically vital; the impact on lean physique mass was not.

When the researchers launched their statistical bag of methods on the info, they seen that the optimistic impact of DHEA on physique composition was defined by the impact of DHEA on the testosterone and estradiol ranges.

They discovered no statistically vital results of DHEA on bone mass, ldl cholesterol steadiness or the focus of triglycerides and glucose within the blood.

Dehydroepiandrosterone supplementation in aged males: a meta-analysis research of placebo-controlled trials.

Summary

CONTEXT:
Age-related dehydroepiandrosterone (DHEA) deficiency has been related to a broad vary of organic abnormalities in males.

OBJECT:
Our goal was to meta-analyze all double-blind, placebo-controlled randomized trials (RCTs) investigating the impact of oral DHEA (DHEA supplementation) as compared with placebo on sexual and metabolic outcomes in aged males.

DATA SOURCE:
An intensive Medline Embase and Cochrane search was carried out together with the next phrases: DHEA, RCTs, and males.

STUDY SELECTION:
Solely double-blind placebo-controlled trials carried out in aged males have been included.

DATA EXTRACTION:
Knowledge extraction was carried out independently by 2 of the authors (A.S. and V.G.), and conflicts have been resolved by the third investigator (G.C.). The standard of RCTs was assessed utilizing the Cochrane standards.

RESULTS:
Of 220 retrieved articles, 25 have been included within the research. The out there RCTs enrolled 1353 aged males, with a imply follow-up of 36 weeks. DHEA supplementation was related to a discount of fats mass (standardized imply distinction of -0.35 [-0.65 to -0.05]; P = .02). Nonetheless, the affiliation with fats mass disappeared in a multivariate regression mannequin after adjusting for DHEA-related metabolite will increase resembling whole testosterone and estradiol. In distinction to what was noticed for fats mass, no impact of DHEA supplementation as compared with placebo was noticed for varied medical parameters together with lipid and glycemic metabolism, bone well being, sexual perform, and high quality of life.

CONCLUSIONS:
The current meta-analysis of intervention research reveals that DHEA supplementation in aged males can induce a small however vital optimistic impact on physique composition that’s strictly depending on DHEA conversion into its bioactive metabolites resembling androgens or estrogens.

PMID: 23824417 DOI: 10.1210/jc.2013-1358 [Indexed for MEDLINE]

Supply: https://www.ncbi.nlm.nih.gov/pubmed/23824417